Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

512
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
512
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

300
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
300
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.0K
Polygenic Traits01:18

Polygenic Traits

66.5K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.5K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Multi-omic modelling of body mass index response to a dietary weight loss intervention.

Gut microbes·2026
Same author

Genetic Determinants of Pulmonary Artery Size in over 50,000 Subjects with and without COPD.

medRxiv : the preprint server for health sciences·2026
Same author

Multi-ancestry modeling improves fine-mapping resolution, protein prediction, and discovery for proteome-wide association studies.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic and transcriptomic determinants of disseminated coccidioidomycosis identify a founder variant in <i>NLRX1</i> and ancestry-specific rare variants in immune response genes.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic drivers of etiologic heterogeneity in thyroid cancer.

Nature communications·2026
Same author

A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner.

Nature genetics·2026

関連する実験動画

Updated: Sep 9, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

540

COPDとCOPD悪化の多層性ポリジェニックスコアは,薬剤可抗性タンパク質を伴う

Chengyue Zhang, Iain R Konigsberg, Yixuan He

    medRxiv : the preprint server for health sciences
    |September 5, 2025
    PubMed
    まとめ

    多特性の多遺伝子スコア (PRS) の開発は慢性閉塞性肺疾患 (COPD) の予測を向上させ,潜在的な薬標的を特定します. このアプローチは,COPDと悪化のリスク評価を改善します.

    さらに関連する動画

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
    05:53

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

    Published on: June 21, 2018

    10.2K
    Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
    08:51

    Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

    Published on: September 20, 2024

    1.5K

    関連する実験動画

    Last Updated: Sep 9, 2025

    Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
    10:21

    Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

    Published on: September 20, 2024

    540
    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
    05:53

    Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

    Published on: June 21, 2018

    10.2K
    Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
    08:51

    Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

    Published on: September 20, 2024

    1.5K

    科学分野:

    • 遺伝学とゲノミクス
    • 肺医学
    • 精密医療

    背景:

    • 慢性閉塞性肺疾患 (COPD) は,世界的に大きな健康問題となっています.
    • COPDのリスクと悪化を正確に予測することは,効果的な管理に不可欠です.
    • 現在の予測モデルは COPDの複雑な遺伝的および生物学的基盤を完全に捉えていない可能性があります.

    研究 の 目的:

    • COPDと悪化を予測するための多特質ポリジェニックスコア (PRS) の開発と検証
    • COPDにおける潜在的治療標的となるPRS関連タンパク質を特定する.
    • 多特質PRSの性能を単一特質PRSと比較して評価する.

    主な方法:

    • 7つの特性を複合PRS (PRSmulti) に組み込むマルチ特性のPRSフレームワークであるPRSmix+を使用した.
    • COPDGene,ECLIPSE,All of Us,UK Biobank を含む多様な潜在的なコホートでPRSmultiを検証しました.
    • PRSに関連したタンパク質を特定し,検証し,既存の薬や試験中の薬と関連付けるためのプロテオミクデータと統合されたPRS

    主要な成果:

    • 複合PRS (PRSmulti) は,コホート全体におけるCOPD状態と悪化頻度との有意な関連性を示した.
    • PRSmultiは予測精度において従来の単一特性のPRSを上回った.
    • 特定された73のPRS関連タンパク質は,AGER,IL1RL1,SCARF2を含む25の薬物標的と関連している.

    結論:

    • マルチトラットPRSは,COPDと悪化リスクの予測を改善します.
    • PRSをプロテオミクデータと統合することで 新しく薬効性のある治療目標が成功しています
    • このアプローチは,COPDの管理における精密医療の進歩のための有望な戦略です.