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Updated: Sep 9, 2025

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

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エンドプラズマ網膜ストレスによるCXCL8誘導は,SMAD2/3の活性化により食道状細胞癌の移行と侵入を促進する

Junhong Wu1, Fangyu Su1, Juntao Lu1

  • 1Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

Molecular medicine reports
|September 5, 2025
PubMed
まとめ

エンドプラズマ網膜のストレス (ERS) は食道状細胞癌 (ESCC) のCXCL8を上調する. このCXCL8は,CXCL8-CXCR1/2-SMAD2/3-SNAI2/ZEB1軸経由で癌細胞の移動と侵入を促進し,上皮-メゼンキマ移行 (EMT) を推進する.

キーワード:
C-X-Cモチーフ・ケモカイン・リガンド 8スマッド2/3エンドプラズマの網膜のストレスエソファゲスの状細胞癌

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