胎児のアトピー性皮膚炎における妊婦の食事の多様性の影響:台湾の出生コホートにおける微生物群の関連性
Linh Ba Phuong Huynh1, Hsien-Yu Fan1, Shih-Yi Huang1,2,3
1School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.
まとめ
妊娠中の母親の食事の多様性は,乳児のアトピー性皮膚炎のリスクの減少と関連しています. これは乳幼児の腸内微生物の組成の変化を伴い,RothiaやParabacteroidesのような特定の細菌が作用する可能性があります.
科学分野:
- 母親と乳児の健康
- 栄養免疫学
- 微生物群の研究
背景:
- 妊娠中の母親の食事は乳児の免疫発達とアトピー性皮膚炎のリスクに影響します.
- 母親の食事と乳児のアトピー性皮膚炎を結びつけるメカニズムは完全に理解されていません.
研究 の 目的:
- 母親の食事の多様性と乳児のアトピー性皮膚炎の発生率との関連を調査する.
- 赤ちゃんの腸内微生物群を この関係における 潜在的仲介者として探求すること
主な方法:
- 677人の母と乳児の長距離コホート研究
- FAOのガイドラインを使って母親の食事の多様性を評価した.
- 2ヶ月の乳児の腸内微生物群を分析し,3歳までのアトピー性皮膚炎の発生を追跡した.
主要な成果:
- 母親の食事の多様性は子孫のアトピー性皮膚炎リスクの低下と相関する.
- 母親の食事は 赤ちゃんの腸内微生物の組成に 影響を及ぼしましたが 全体の多様性には 影響を及ぼしませんでした
- アトピー性皮膚炎のリスクの減少に関連したロチアおよびパラバクテロイドの豊富さ
結論:
- 妊娠中の母親の食事の多様性が増加すると,幼児期のアトピー性皮膚炎から保護できます.
- 乳児の腸内微生物群が この保護効果を媒介するかもしれません
- 発見を確認し,メカニズムを明らかにするためにさらなる研究が必要です.
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