関連する実験動画

Updated: Sep 9, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
09:04

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

Published on: September 10, 2018

9.8K

胎児,新生児,成人における肝臓クリアランスの新しい成熟方程式:パラセタモールおよびその代謝物への適用

Yunjiao Wu1, Swantje Völler1,2, Sebastiaan C Goulooze3

  • 1Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

Journal of clinical pharmacology
|September 5, 2025
PubMed
まとめ

新しい早産と新生児から成人の方程式 (PTNA) は,小児におけるパラセタモール (PCM) の代謝の成熟を正確にモデル化しています. このPTNA方程式は肝臓クリアランスの既存のモデルを上回り,幼児期から成人期までの予測を改善します.

キーワード:
グルキュロニデーション熟成する酸化パラセタモール未熟児硫化

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