多発性硬化症および関連疾患の患者における長期COVID:多センター横断研究
Chen Hu1, Jiyeon Son2, Lindsay McAlpine3
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Annals of clinical and translational neurology
|September 5, 2025
まとめ
多発性硬化症および関連疾患を持つ人は,特に症状が悪化するから,長期間COVIDに罹患する確率が高くなります. 長いCOVIDは,この集団における機能と障害を著しく悪化させる.
科学分野:
- 神経学
- 感染症
- 公衆衛生
背景:
- 多発性硬化症および関連疾患 (pwMSRD) の患者の長期COVIDの管理は,重複する症状のために課題を提示します.
- 既存の証拠のギャップは,長期のCOVID感受性とそのpwMSRDへの影響に関する研究を必要とします.
研究 の 目的:
- pwMSRDにおける長期のCOVID感受性を,対照群と比較して評価する.
- pwMSRDにおける多領域機能と障害との関連を評価する.
主な方法:
- 969人のpwMSRDと1003人の対照群を対象とした多センター横断試験です.
- 参加者は,新発症と悪化した症状を区別する71の感染後の症状に関する調査を完了しました.
- 長いCOVIDは2024 NASEM基準を使用して定義され,ロジスティックおよび回帰分析が採用されました.
主要な成果:
- PwMSRDは長期COVIDの確率が高く (aOR=1.6),症状が悪化する確率はより高い (aOR=2.3).
- 長いCOVIDは,身体機能の低下,認知能力の低下,および両方のグループにおけるうつ病の増加と相関しています.
- 長期COVIDに罹患したPwMSRDは,より大きな機能低下,うつ病の悪化,そしてより速い障害の進行を経験しました.
結論:
- PwMSRDは,主に症状の悪化によって長期間COVIDへの感受性が高まっていることを示しています.
- 長期のCOVIDは,pwMSRDにおける機能的低下と障害の悪化に大きく寄与する.
- 長期COVIDの早期発見と管理は,pwMSRDの改善に不可欠です.
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