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関連する概念動画

Fluid Mosaic Model01:19

Fluid Mosaic Model

12.7K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
12.7K
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

2.8K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
2.8K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.1K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.1K
The Fluid Mosaic Model01:34

The Fluid Mosaic Model

151.9K
The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.
151.9K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.5K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.5K
Membrane Fluidity01:23

Membrane Fluidity

155.6K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
155.6K

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関連する実験動画

Updated: Sep 9, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
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Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

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任意の形状の粒子の膜相互作用の細胞スケールダイナミックモデリング

Didarul Ahasan Redwan1, Justin Reicher2, Xin Yong1,2

  • 1Department of Mechanical and Aerospace Engineering, University at Buffalo, Buffalo, NY 14260, USA. xinyong@buffalo.edu.

Soft matter
|September 5, 2025
PubMed
まとめ

この研究は,細胞膜と不規則な形状の粒子の間の相互作用をモデル化するための計算フレームワークを導入します. 低粒子対小胞質量比は完全な膜包みを促進し,高い比は部分包みにつながります.

さらに関連する動画

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
10:02

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

Published on: May 27, 2021

4.1K
Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.3K

関連する実験動画

Last Updated: Sep 9, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

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Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
10:02

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions

Published on: May 27, 2021

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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
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Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

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科学分野:

  • バイオ物理学
  • コンピュータ生物学
  • 材料科学

背景:

  • 複雑な粒子の幾何学を持つ細胞スケールの膜相互作用をモデル化することは計算的に困難です.
  • 既存の方法は,変形性膜と相互作用する任意の形状の粒子の結合変換と回転ダイナミクスを捉えるのに苦労しています.

研究 の 目的:

  • 脂質ベジクルと固い,任意の形状の粒子の間のダイナミックな相互作用をシミュレートするための汎用的な計算フレームワークを開発する.
  • 粒子の形状と質量比が膜変形と包装ダイナミクスに及ぼす影響を調査する.

主な方法:

  • フォースベースの計算フレームワークで,バシクルと粒子の表面に三角化されたメッシュを使用します.
  • 膜変形と固体粒子運動をシミュレートするランゲヴィンダイナミクス
  • 2つの粘着相互作用モデル:頂点から頂点へのマッピングと頂点から表面への投影,後者はより高い精度を示しています.

主要な成果:

  • このフレームワークは,様々な粒子形 (立方体,棒形,ボウル形,四面体) と膀形 (球形,葉巻形,二角形) の相互作用をうまくシミュレートします.
  • 粒子の重量比が低く,粒子の方向転換と完全な膜包装が促進されます.
  • 高質量比は粒子の方向転換を制限し,安定した部分膜包み方を好みます.

結論:

  • 開発されたフレームワークは,膜-粒子相互作用の予測的,細胞規模の研究のための一般化可能なアプローチを提供します.
  • このツールは環境生体物理学 (例えばマイクロプラスチック) とナノ医療に潜在的応用がある.