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Updated: Sep 9, 2025

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
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Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+

Published on: May 19, 2017

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サルコ・エンドプラズマ網膜カルシウムポンプの活性化に必要なダワーフ・オープン・リーディング・フレームの構造要素

M'Lynn E Fisher1, Justin R Gregory1, Stan T J Aanhane1

  • 1Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

Biochemistry
|September 5, 2025
PubMed
まとめ

ダワーフ・オープン・リーディング・フレーム (DWORF) はサルコエンドプラズマ網膜カルシウムポンプ (SERCA) を活性化します. この活性化にはDWORFの特定の残留物が不可欠であり,その変異はSERCAの抑制につながり,SERCAの調節に関する重要な構造的洞察を明らかにする.

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