ベンゾジアゼピンの非ラベル処方: プライマリケアにおける処方頻度に関する遡及コホート研究
Kevin Trimm1, Maria-Teresa Moraga2, Bärbel Knäuper3
1Department of Experimental Medicine, McGill University, 845 Sherbrooke Street West, Montreal, QC, H3A 2T5, Canada. kevin.trimm@mail.mcgill.ca.
Clinical drug investigation
|September 5, 2025
まとめ
ベンゾジアゼピンの処方箋は一般的であり,ほぼ半分は,しばしば不眠症のために処方されています. ほとんどの非処方薬には,他のベンゾジアゼピンに対する補足用薬が含まれていた.
科学分野:
- 薬理学について
- 公衆衛生
- 高齢者医療
背景:
- ベンゾジアゼピンは,不安,睡眠,発作,アルコール離脱に広く処方されています.
- ベンゾジアゼピンの乱用と害に関する懸念は,特に高齢者の間で存在します.
- 治療用薬の指示に関するデータが限られているため,非処方薬の処方パターンを理解することは極めて重要です.
研究 の 目的:
- ベンゾジアゼピンの非公式処方薬の普及率を決定する.
- ベンゾジアゼピンの使用に関する一般的な指示を特定する.
主な方法:
- カナダのケベック州のMOXXIシステムからの電子医療記録データを利用しました.
- Health Canadaのガイドラインによると,レセプション用薬は,レセプション用薬と非レセプション用薬に分類されています.
- 同様のベンゾジアゼピンに対するカナダ保健省の承認に基づいて,非表示処方薬の"クラス一致性"を評価した.
主要な成果:
- ベンゾジアゼピンを受けた患者の17. 0%; 主に高齢の女性 (平均年齢60. 14)
- 処方箋 (49. 3%) と非処方箋 (49. 2%) の割合はほぼ同じでした.
- ほとんどの非処方薬 (95. 2%) はクラス一致を示し,不眠症は最も頻繁な指標でした.
結論:
- ベンゾジアゼピンは,ケベックで頻繁に処方され,ラベル外で大量に使用されています.
- オフレーベル処方には,しばしば他のベンゾジアゼピンに承認された指示が含まれます.
- ベンゾジアゼピンの処方箋は,不眠症が主な原因で,クラス一致性があります.
さらに関連する動画
06:59A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
30.6K
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
19.9K
関連する概念動画
01:19Sedatives and Hypnotics Drugs: Benzodiazepines
373
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
373
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
1.2K
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
1.2K
01:14CNS Depressants: Barbiturates and Benzodiazepines
462
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
462
01:26Anxiolytic Drugs: Overview
479
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
479
01:23Sedatives and Hypnotics: Overview
629
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
629
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
236
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
236