Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.1K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.9K
Bone Remodeling01:40

Bone Remodeling

38.5K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.5K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

5.4K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
5.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Nutritional Support for Treatment Continuity and Survival in Advanced Gastric Cancer: A Propensity Score-matched Study.

In vivo (Athens, Greece)·2026
Same author

Bee larvae ameliorate andropause-like symptoms via a hormone-independent, antioxidant mechanism.

Frontiers in physiology·2026
Same author

Clinical Outcomes in Advanced Gastric Cancer Among Patients Aged ≥80 Years Treated With Chemotherapy.

Anticancer research·2026
Same author

Pyroxylin shortens the resting stage of the hair cycle in mice.

Scientific reports·2026
Same author

Real-world platinum selection in immune checkpoint inhibitor-based therapy for recurrent or metastatic head and neck cancer: an exploratory multi-institutional retrospective study.

Scientific reports·2026
Same author

Fluid shear stress activates c-Src and promotes RANKL localization in the plasma membrane in osteoblast-like MC3T3-E1 cells.

BBA advances·2026

関連する実験動画

Updated: Sep 8, 2025

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

9.5K

セバシウム酸は骨質細胞の分化を促進する

Thira Rojasawasthien1,2, Takumi Ito3, Hideto Okamoto4

  • 1Division of Biochemistry, Kyushu Dental University, Kitakyushu, Japan.

Bioscience, biotechnology, and biochemistry
|September 5, 2025
PubMed
まとめ

ロイヤルゼリーの代謝産物であるセバシウム酸 (SA) と2デセノ酸 (2DA) は,骨の健康について研究された. セバシク酸は2DAとは異なり,骨細胞の分化と骨マーカー遺伝子発現を有意に促進した.

キーワード:
2デセニオ酸 (2DA)オステオブラスト生成ロイヤルゼリー10ヒドロキシデカノ酸 (10HDAA)脂肪酸 (SA)脂肪酸

さらに関連する動画

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.5K
Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

1.8K

関連する実験動画

Last Updated: Sep 8, 2025

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

9.5K
Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.5K
Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

1.8K

科学分野:

  • 生物化学
  • 骨の生物学
  • 栄養薬

背景:

  • ロイヤルゼリー (RJ) には,10-ヒドロキシ-2-デセノ酸 (10H2DA) と10-ヒドロキシデセノ酸 (10HDAA) のような脂肪酸が含まれています.
  • これらのRJ脂肪酸は肝臓で2デセノ酸 (2DA) とセバシ酸 (SA) に代謝されます.
  • これらの代謝産物の骨代謝における役割については,さらなる調査が必要である.

研究 の 目的:

  • 2DAとSAが骨格細胞の分化に及ぼす影響を調査する.
  • RJメタボリットの骨の健康への特定の貢献を理解する.

主な方法:

  • 骨髄細胞の系統細胞を in vitro 試験に使用した.
  • 細胞培養に2DAとSAを投与した.
  • オステオブラストマーカー遺伝子発現とアルカリリンファスファターゼの活性を測定した.

主要な成果:

  • セバシク酸 (SA) は重要な骨格細胞マーカー遺伝子を有意に上昇させました.
  • SA治療はアルカリリンフォスファターゼの活性を増強し,分化が増加したことを示した.
  • 2デセノ酸 (2DA) は骨質細胞の分化に有意な効果を示さなかった.

結論:

  • ロイヤルゼリーの代謝産物であるセバシ酸は,骨格細胞の分化を促進する.
  • SAは,ロイヤルジェリーに起因する骨代謝の利点において重要な役割を果たす可能性があります.
  • 骨の健康におけるSAのメカニズムに関するさらなる研究が必要である.