咳のピークフロー,胸壁の体積,およびアミオトロフィック横筋硬化症の患者の呼吸パターンの急性効果
Rayane G S Vieira1, Íllia N D F Lima1, Karen M Pondofe1
1Ms. Vieira, Dr. Lima, Dr. Pondofe, Ms. Maciel, Dr. da Fonsêca, Dr. Resqueti, and Dr. Fregonezi, are affiliated with the Departamento de Fisioterapia, PneumoCardioVascular Lab/HUOL and the Laboratório de Inovação Tecnológica em Reabilitação, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Respiratory care
|September 5, 2025
まとめ
脊髄発症のALS患者の咳のピークフロー (CPF) を改善する. しかし,MI-Eは胸壁の体積や呼吸パターンを有意に変化させなかった.
科学分野:
- 神経学
- 肺科
- 回復医療
背景:
- アミオトロフィック横筋硬化症 (ALS) は呼吸器障害,肺の体積の減少,効果のない咳を引き起こし,著しい罹病率と死亡率をもたらします.
- 機械的吸入-吸出 (MI-E) は,咳のピークフロー (CPF) を強化し,分泌のクリアランスを促進することを目的として,吐出空気流を増やすように設計された技術です.
- ALSの進行を制御するには,MI-Eが呼吸器系に与える影響を評価することが重要です.
研究 の 目的:
- 咳のピークフロー (CPF) に対するMI-Eの直接的な効果を評価する.
- 胸壁のコンパートメントと動作容量に対するMIEの影響を評価する.
- ALS患者のMI- E投与中に呼吸パターンと呼吸器の機能の変化を調査する.
主な方法:
- ALS の 10 名の患者は,胸壁の運動を測定するために,光電子プレチスモグラフィー (OEP) を受けました.
- CPF,呼吸パターン,および呼吸器の筋肉機能は,MI- Eの適用前,その間,およびその後に評価された.
- 分析は,胸壁の総体と区間の体積の変動と肺の活動体積に焦点を当てた.
主要な成果:
- 全体として,CPFの有意な差異は,MIE前,その間,およびその後の時間点では観察されなかった.
- 脊髄発症ALSの患者では,MI-Eの直後にCPFの有意な増加が認められた (n=7).
- MI- Eの間やその後,肺の総体積や区画体積,胸壁の動作量に重大な変化は認められなかった.
結論:
- MI-Eは,特に脊髄発症のALS患者において,CPFを増加させることで利益をもたらす可能性があります.
- この研究では,研究されたALSコホートでは,MI- Eに起因する胸部容量または呼吸パターンの有意な変化は見られなかった.
- MI- E治療から最も恩恵を受けるかもしれない長期的な効果と特定の患者のサブグループを調査するために,さらなる研究が必要である.
関連する概念動画
Physical Assessment of the Respiratory Tract II: Inspection
406
Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration...
Chest Configuration
The chest configuration...
406
Factors Affecting Pulmonary Ventilation
1.6K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.6K
Alterations in Respiration II
1.0K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.0K
Assessment of Ventilation II: Respiratory Depth and Rhythm
1.8K
Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
1.8K
Mechanical Ventilation II: Invasive Ventilation
253
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
253
Physical Assessment of the Respiratory Tract IV: Auscultation
701
Auscultation is a crucial component of the physical assessment of the respiratory tract. It offers valuable insights into airflow through the bronchial tree and potential lung obstructions. This process involves careful listening to breath, voice, and adventitious sounds, which can reveal a wealth of information about a patient's respiratory health.
Breath Sounds
Breath sounds are categorized into vesicular, bronchovesicular, and bronchial.
Breath Sounds
Breath sounds are categorized into vesicular, bronchovesicular, and bronchial.
701


