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Updated: Sep 8, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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抗ウイルス免疫を活性化し,がん免疫療法を強化する

Fan Wang1, Yu Tong1, Wenyun Guo1

  • 1State Key Laboratory of Systems Medicine for Cancer, Department of Liver Surgery, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cell reports
|September 5, 2025
PubMed
まとめ

Pseudouridine synthase 1 (PUS1) は,先天的な抗ウイルス信号を抑制することで,腫瘍の免疫回避を促します. PUS1または偽ウリジン合成を阻害すると,dsRNA感知経路を活性化することで,抗PD-1療法の有効性を高めます.

キーワード:
CP: がんについてRIG-I 信号経路免疫回避偽ウリジン合成酵素 1腫瘍の進行

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