ケトジニック・ダイエット,時間制限食,または日替わりの断食が,外出血圧の変化に及ぼす影響. ランダム化臨床試験のサブ分析
Ana María Gómez-Pérez1,2, Borja Bandera-Merchán1,2,3, José Ignacio Martínez-Montoro1,2
1Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA-BIONAND Platform), University of Malaga, 29016 Malaga, Spain.
European journal of preventive cardiology
|September 5, 2025
まとめ
改定型アルターネイトデイ・ファスト (mADF) は,肥満患者の血圧を効果的に低下させ,他のダイエットを上回った. この減量介入は,24時間の出院式血圧モニタリング (ABPM) パラメータにおいて有意な改善を示した.
科学分野:
- 心血管の健康
- メタボリックシンドローム
- 栄養学
背景:
- 肥満は高血圧の重要な危険因子ですが,体重減少と血圧低下のための食事介入に関する証拠は限られています.
- 低カロリーダイエットが 血圧に与える影響を理解することは 肥満に関連する心血管疾患の 管理に不可欠です
研究 の 目的:
- 肥満の個体において,異なる低カロリーダイエットによる24時間出院式血圧モニタリング (ABPM) パラメータの変化を評価する.
- 早期の時間制限食 (eTRE),夕方の時間制限食 (lTRE),改変された交代日断食 (mADF),ケトーゲンダイエット (KD) と地中海ダイエット (CG) の血圧低下の効果を比較する.
主な方法:
- 肥満 (BMI > 30kg/ m2) の96人の参加者を対象とした単一センター,並列群のランダム化比較試験.
- 参加者は5つのグループにランダムに分けられました: eTRE,ltRE,mADF,KD,CG (地中海ダイエット).
- 24時間ABPMは食事介入前と後に実施された.
主要な成果:
- すべての食事介入は統計的に有意な人体測定変化をもたらした.
- mADFグループは,ABPMのほとんどのパラメータにおいて,最も実質的な改善を示しました.
- 他のグループではABPMの有意な変化はなかった.
- 線形混合モデリングでは,mADFが24時間の収縮血圧の低下に影響を与えたことが示された.
結論:
- 体重減少のための食事介入は,ケトジェニックの可能性が異なるが,血圧低下に異なる効果を示している.
- 身体の組成やケトンのレベルに関係なく,血圧を改善するための最も効果的な戦略として, 改変されたアルターネイトデイ・ファスト (mADF) が登場しました.
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