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Updated: Sep 8, 2025

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
06:27

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy

Published on: November 30, 2018

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アルツハイマー病の連続体に沿ってプラズマの膠状線維酸性タンパク質の緩和効果

Shannon Y Lee1, Valentina E Diaz2, Olivia M Emanuel1

  • 1Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 5, 2025
PubMed
まとめ

GFAPはアルツハイマー病 (AD) の進行に影響を与える. 血のGFAP濃度が高いと,ADのバイオマーカー,神経変性,認知機能低下との関連が強化され,より高いリスクのある個人を特定できます.

キーワード:
ATN についてアルツハイマー病GFAP についてアストロサイトの反応性認知能力状繊維酸性タンパク質炎症神経変性神経炎症神経病理学プラズマのGFAPプラズマバイオマーカー

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

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Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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