COVID-19患者の急性腎臓疾患 ラテンアメリカにおける多中心の多国籍研究
Raúl Lombardi1, Alejandro Ferreiro1, Yanissa Venegas2
1Universidad de la República, Facultad de Medicina, Centro de Nefrología, Montevideo, Uruguay.
Jornal brasileiro de nefrologia
|September 5, 2025
まとめ
急性腎臓病 (AKD) は,タンパク質尿と急性腎臓損傷 (AKI) に関連した死亡率が高いCOVID-19患者の75%以上に影響します. これはAKDを強調しています.
科学分野:
- 腎臓科
- 感染症
- クリティカル ケア 医療
背景:
- 急性腎臓病 (AKD) は90日以内の腎臓異常を含む.
- COVID-19は,タンパク質尿や機能障害を含む腎臓機能障害を伴う.
- AKDの評価は,これらの条件に適した枠組みを提供します.
研究 の 目的:
- 病院に入院しているCOVID-19患者の急性腎臓病 (AKD) の罹患率と影響を評価する.
- タンパク質尿と急性腎損傷 (AKI) を含むAKD基準を用いて腎機能障害を分類する.
- AKDの重症度と入院死亡率の関係を分析する.
主な方法:
- 観察的,前向きな,縦断的な,多国籍コホート研究.
- ラテンアメリカの5か国における成人COVID-19患者を含む.
- AKDの患者様を4つのカテゴリーに分類する.
主要な成果:
- COVID-19患者の75.8%がAKDを発症した.
- プロテイン尿は72. 8% , AKIは36. 4%であった.
- 病院での死亡率はAKDの重症度によって9. 5%から53%以上に大幅に増加しました.
結論:
- この研究は,急性腎疾患 (AKD) の概念を用いた統合的アプローチを支持しています.
- AKDは,より良い管理のためにAKI,AKD,CKDを含む連続性を提供します.
- このアプローチは 腎臓機能不全の早期介入と予防戦略を容易にする.
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