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Senkyunolide Iは,JAK1/3-STAT3/6とJNKのシグナル伝達を阻害することで,アレルギー性鼻炎を軽減する

Ting Liu1, Tian Wen2, Xiaofei Shen2

  • 1Department of Otolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; TCM Prevention and Treatment of Metabolic and Chronic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

International immunopharmacology
|September 5, 2025
PubMed
まとめ

Senkyunolide I (SEI) は,炎症メディエーターを減らし,JAK/ STATおよびJNKのような重要なシグナル伝達経路を阻害することによって,アレルギー性鼻炎 (AR) を効果的に治療します. この天然の化合物は,ARやその他のアレルギー疾患の治療に有望です.

キーワード:
アレルギー性鼻炎IL-4 についてJAK1/3 についてJNK についてSTAT3/6 についてセンキュノライドI

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