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Updated: Sep 8, 2025

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
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RNF207は,KCNQ1によるERK/MEKシグナル伝達経路の活性化により,骨肉腫の増殖,移動および侵入を促進する

Wenda Liu1, Kezhou Xia1, Kai Tong1

  • 1Department of Orthopaedics, Renmin Hospital of Wuhan University, Hubei Province, Wuhan 430060, China.

International immunopharmacology
|September 5, 2025
PubMed
まとめ

輪指タンパク質207 (RNF207) は骨肉腫において上昇し,がんの成長を促進し,予後が悪い. それはKCNQ1を分解し,MAPKシグナリングを活性化し,RNF207を潜在的治療標的とする.

キーワード:
KCNQ1MAPK信号経路マススペクトロメトリーオステオサルコマRNF207 について

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