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Updated: Jun 4, 2026

Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain
10:01

Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain

Published on: October 25, 2017

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ゼブラフィッシュのナノアルミナ誘発性認知機能障害におけるBDNF/TrkB信号経路の調節におけるRESTの役割

Jingsi Zhang1, Shanshan Wang1, Zhaoya Jin1

  • 1Key Laboratory of Coal Environmental Pathogenicity and Prevention, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

Ecotoxicology and environmental safety
|September 5, 2025
PubMed
まとめ

アルミニウムナノ粒子 (AlNPs) は,REST調節されたBDNF/TrkBシグナル伝達を妨害し,シナプス可塑性に影響を及ぼします. RESTのノックダウンはこれらの神経毒的効果を軽減し,環境ナノマテリアルのリスクの洞察を提供します.

キーワード:
BDNFについてナノアルミニウム酸化物REST についてシナプスの可塑性ゼブラフィッシュ

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