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Updated: Sep 8, 2025

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies
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皮下組織とリンパ液における分解が,皮下投与後のFc融合タンパク質の吸収に与える影響

Miki Yokoyama1, Eiko Suzuki1, Daisuke Nakai1

  • 1Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.

Drug metabolism and pharmacokinetics
|September 5, 2025
PubMed
まとめ

皮下Fc融合タンパク質の生物利用性は,吸収中のタンパク質の分解によって影響されます. 完ぺきなタンパク質を測定すると,生物学的利用性が低下し,分解が薬効性に影響することを示す.

キーワード:
抗体生物学的利用可能性Fc融合タンパク質薬理学皮下投与

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