関連する実験動画
Updated: Sep 8, 2025

07:07
A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
12.5K
メラノーマに対するCOVID-19パンデミックの影響:フランスのメラノーマ患者の臨床データベース (RIC-Mel) の遡及的研究
F Skowron1, S Mouret2, A Seigneurin3
1Hôpitaux Drôme Nord, Romans-Sur-Isère, France.
Annales de dermatologie et de venereologie
|September 5, 2025
まとめ
フランスでのCOVID-19のパンデミックは,より重症なメラノーマの診断につながり,腫瘍がより厚く,潰瘍性になりました. これは,パンデミック期間中に検出された薄いメラノーマが少ないことによる.
科学分野:
- 腫瘍学
- 皮膚科
- 流行病学について
背景:
- COVID-19 パンデミックは,様々な病気の臨床的表象と重症性に様々な影響を及ぼしてきました.
- メラノーマは 皮膚がんの重要な形態で 適切な診断と治療が必要です
- メラノーマのような慢性的で重篤な疾患の管理には パンデミックに起因するヘルスケアの障害を理解することが重要です
研究 の 目的:
- フランスにおけるメラノーマ症例の初期診断の重症度に対するCOVID-19の影響について調査する.
- メラノーマの特徴と診断のタイムラインを 流行前の時期と流行前の時期に比較する.
- COVID-19 時代における腫瘍の厚さ,潰瘍,およびステージの変化を評価する.
主な方法:
- フランスのRIC-Melデータベースからの新しいメラノーマ症例の遡及分析.
- 3つの異なるタイムフレーム:COVID前,ロックダウン,より広範なCOVIDパンデミック期間 (11/05/2020〜30/09/2022) を含む.
- 患者とメラノーマの特徴の統計的比較,腫瘍の段階,潰瘍,治療までの時間,COVID前とCOVID期間の比較.
主要な成果:
- COVID期間に診断されたメラノーマは,COVID前期と比較して,著しく厚み (1.5 mm 対 1.2 mm) が高く,より頻繁に潰瘍を発症した (25.4% 対 20.6%).
- 特に薄型メラノーマ (TisとT1段階) の毎日の診断率の減少が観察されました.
- COVID期間中に進行した腫瘍 (T2,T3,T4) とステージIIIのメラノーマの診断が顕著に増加し,センチネルリンパ節生検率と陽性と並行した.
結論:
- フランスにおけるCOVID-19のパンデミックは,重症メラノーマの診断の割合が高かった.
- メラノマの検出と診断の減少が 重要な要因であるようです
- これらの発見は,公衆衛生上の危機の間,早期の癌の診断が遅れたり,失敗したりする可能性を強調しています.
関連する概念動画
Cancer Survival Analysis
445
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
445
Skin Cancer
4.5K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.5K
Changes in Skin Color: Clinical Perspectives
2.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.2K
Clinical Trials
7.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
7.5K
Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K

