関連する実験動画

Updated: Sep 8, 2025

Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis
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Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis

Published on: May 10, 2019

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標的RNA認識は,トランポゾン静音化のためのPIWI複合組成を駆動する

Júlia Portell-Montserrat1, Laszlo Tirian2, Changwei Yu2

  • 1Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria; Institute of Molecular Pathology (IMP), Campus Vienna BioCenter, 1030 Vienna, Austria; Vienna BioCenter PhD Program, Doctoral School of the University of Vienna, Medical University of Vienna, Vienna, Austria.

Molecular cell
|September 5, 2025
PubMed
まとめ

PIWI相互作用RNA (piRNA) とPIWIタンパク質は,PIWI*複合体を形成することによってトランポゾンを静止させます. これらの複合体は下流エフェクターの採用のプラットフォームとして機能し,ゲノムの完全性を保証します.

キーワード:
アルゴナウトのタンパク質ドロソフィラPIWI-piRNA経路について細菌系生物学ヘテロクロマチン生物学piRNAバイオゲネシスタンパク質構造の予測小型RNA経路トランポゾンサイレンス

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