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血清ビタミンDメタボリットのレベルとコミュニティに住む高齢者の認知機能との関連:横断的な研究
Cai Yu1, Minae Ide1, Taiki Sugimoto2
1Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, 2-1-132, Osaka-shi, Osaka 536-8525, JAPAN.
Clinical nutrition ESPEN
|September 5, 2025
まとめ
ビタミンDの代謝物質の総量25~OH) Dを超えると 認知の健康に関する新しい洞察が得られます 特定の代謝産物と比率は,認知機能とアルツハイマー病のリスクとの性依存関係を示しています.
科学分野:
- 神経科学と内分泌学
- ビタミンDの代謝の生化学
背景:
- ビタミンD欠乏症は認知機能低下とアルツハイマー病 (AD) と関連しているが,結果は矛盾している.
- 合計25-ヒドロキシビタミンD [25(OH) D]は,ビタミンDの役割を完全に捉えることができないかもしれません. 24,25-二ヒドロキシビタミンD3 [24,25(OH) 2D3]および3-エピマー-25-ヒドロキシビタミンD3 [3-epi-25(OH) D3]のような他の代謝物は,より情報的であるかもしれません.
研究 の 目的:
- 血清のビタミンD代謝産物濃度と高齢者の認知機能との関連を調べる.
- これらの関連性における 性別に基づく潜在的な違いを探求する.
主な方法:
- AD,軽度の認知障害 (MCI),または認知的に正常な (CN) の289人の成人 (65~85歳) の横断的な研究.
- ミニメンタルステート試験 (MMSE) による認知機能の評価
- LC-MS/MSで測定された25[OH]D3,25[OH]D2,24[OH]2D3,3-epi[OH]25[OH]D3,および1,25-二酸化酸素ビタミンD3の血清濃度 ビタミンDメタボリート比率 (VMR) を計算した.
主要な成果:
- 男性では,3-epi-25 ((OH) D3) と24,25 ((OH) D3) は,MMSEのスコアが低く,ADのリスクが高かった.
- 女性では,VMRはMMSEのスコアが高く,ADのリスクが低かったが,1,25 (OH) 2D3はADのリスクが高かった.
- ビタミンDの代謝産物と認知能力の関係において,性別による差異が観察された.
結論:
- ビタミンDと認知の関連性における性別の違いは,ホルモン要因によって影響される可能性があります.
- 1,25(OH) 2D3,VMR,および3-epi-25(OH) D3などの代謝物は,総25(OH) Dよりも認知健康のより敏感な指標である可能性があります.
キーワード:
24,25-ジヒドロキシビタミンD ((3)) [24,25 ((OH)) ((2) D ((3) ]25-ヒドロキシビタミンD [25(OH) D]3-エピマー-25-ヒドロキシビタミンD ((3)) [3-epi-25 (((OH)) D ((3) ]認知機能ビタミンD代謝率 (VMR)さらに関連する動画
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