関連する実験動画

Updated: Sep 8, 2025

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

8.5K

NOTCHシグナリングは,腎臓アロ移植の拒絶におけるマクロファージの炎症性-繊維性連続体をオーケストラする

Yanxu Chen1, Qiang Zhang1, Wenyu Xie1

  • 1Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, Guangdong 510080, China.

Experimental cell research
|September 5, 2025
PubMed
まとめ

研究者らは,新種のTGFB+CD86+マクロファージのサブセットが腎臓移植の拒絶を誘発していることを特定しました. このサブセットはJagged1-NOTCH2シグナリングによって調節され,炎症と線維症を橋渡しし,慢性的な拒絶に対する潜在的な治療目標を提供します.

キーワード:
NOTCH慢性的な拒絶繊維症腎臓移植マクロファージ

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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