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Updated: Sep 8, 2025

Rescue of Recombinant Newcastle Disease Virus from cDNA
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アフリカブタ熱ウイルスにコードされたpE248Rタンパク質は,RIG-I媒介の抗ウイルス信号を阻害することで,インターフェロン生成を抑制する

Jinyu Zhao1, Chunxiao Mou1, Liqi Zhu1

  • 1College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China.

International journal of biological macromolecules
|September 5, 2025
PubMed
まとめ

アフリカ豚熱ウイルス (ASFV) はpE248Rタンパク質を使用して,RIG-I抗ウイルス経路を遮断することで宿主免疫を回避します. このタンパク質は2つの異なるメカニズムを通してRIG-Iの信号伝達を妨害し,ASFVの免疫脱出を助けます.

キーワード:
アフリカ豚病ウイルスインターフェロンRIG-Iトリム25pE248R について

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