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Updated: Sep 8, 2025

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
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Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

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T細胞受容体レパートリーと骨関節炎におけるHLA: 体系的な文献レビュー

Maria Marco-Salvador1, Marie Binvignat2, Paul Stys1

  • 1Immunology, Immunopathology, Immunotherapy I3 Lab, Inserm UMRS 959, Sorbonne Université, Paris, France.

Osteoarthritis and cartilage
|September 5, 2025
PubMed
まとめ

骨格関節炎 (OA) のT細胞受容体 (TCR) 免疫に関する研究は限られている. 主にヒト白血球抗原 (HLA) に関する現在の研究は,OAにおけるT細胞の役割を定義するのに十分なデータと高通量分析を欠いている.

キーワード:
適応免疫人間の白血球抗原メジャー・ヒストコンパティビリティ・コンプレックス骨関節炎体系的な文献レビューT細胞受容体

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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