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Updated: May 29, 2026

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転移性腎臓細胞癌におけるTKIと免疫療法に対する反応を予測する免疫抑制微環境のバイオマーカーとしてのKPNA2発現

Xianglai Xu1, Xin Xie2, Jiajun Wang3

  • 1Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Urology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.

European journal of pharmacology
|September 5, 2025
PubMed
まとめ

カリオフェリンアルファ2サブユニット (KPNA2) は,進行性腎臓がん (RCC) 治療に対する反応を予測する. 低KPN2発現は,免疫療法とチロシンキナーゼ阻害剤によるよりよい結果を示し,高KPN2発現は,耐性を示唆する.

キーワード:
免疫療法KPNA2 について腎臓細胞がんT細胞の疲労と機能障害タイロシンキナーゼ阻害剤

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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