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Updated: Sep 8, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

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Usnoflast: 最先端のNLRP3阻害剤が,様々な免疫病理における結腸炎を緩和する

Manoranjan Sharma1, Jogeswar Mohapatra1, Hiren Patel1

  • 1Zydus Research Centre, Zydus Lifesciences Limited, Sharkhej-Bavla NH No. 8A, Village Moraiya, Changodar, Ahmedabad-382 213, Gujarat, India.

European journal of pharmacology
|September 5, 2025
PubMed
まとめ

新型NLRP3炎症ホルモンのUsnoflastは,複数の臨床前モデルで腸炎症を効果的に軽減しました. この薬は 炎症経路を標的として 潰瘍性大腸炎のような 自己免疫疾患の 治療の可能性を示しています

キーワード:
デクストラン・ナトリウム硫酸炎症性腸疾患NLRP3 についてS. ティフィムリウムウズノフラストサイトカイン

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat09:04

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Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

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