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Updated: Sep 8, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

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変異体 rs13045は,EIF2AK3の発現を低下させ,川崎病におけるMAPK-ERK1/2経路経由による炎症性サイトカイン分泌を抑制する

Wan Yang1, Wenli Guo2, Zhouping Wang3

  • 1Department of Clinical Biological Resource Bank, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China; Department of Cardiac Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China; Department of Pediatrics, the Affiliated Qingyuan Hospital (Qingyuan People's Hospital), Guangzhou Medical University, Qingyuan, 511518, China.

Biochimica et biophysica acta. Molecular basis of disease
|September 5, 2025
PubMed
まとめ

この研究は,EIF2AK3を川崎病 (KD) の感受性における新たな遺伝因子として特定した. EIF2AK3をターゲットにすることで,炎症を軽減することで,KD血管炎の新たな治療戦略を提供することができる.

キーワード:
EIF2AK3 についてカワサキ病MAPK-ERK1/2経路について炎症を誘発するサイトカインrs13045 バリアント

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