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Updated: May 6, 2026

Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry CCMS
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Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry CCMS

Published on: December 20, 2010

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アクティビティベースの探査と化学プロテオミクスは,メバルナート経路におけるHMGCS1を標的とした生物学的影響を明らかにする

Sang Ah Yi1, Liang Sun1, Yi Rao2

  • 1Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The Journal of biological chemistry
|September 5, 2025
PubMed
まとめ

ヒメグルーシンでメヴァロナート経路酵素HMGCS1を阻害すると,HMGCRの抑制効果が反映されます. HMGCS1とHMGCRの阻害を組み合わせると,スタチン耐性がんに対して有望な結果が得られるが,ヒメグルーシンには長期研究における限界がある.

キーワード:
HMGCR についてHMGCS1 についてヒメグルーシンメバロナートアクティビティベースのプローブ化学プロテオミクススタチン

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