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Updated: Sep 8, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
09:16

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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セルラー・フィブロネクチンは,インテグリンα4β1媒介によるPARP1およびSCDの上昇によってα-シヌクレインの結合を悪化させる.

Zifeng Huang1, Hui Zhong1, Yingqiong Lu2

  • 1Department of Neurology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510280, PR China.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
|September 5, 2025
PubMed
まとめ

細胞フィブロネクチン (cFn) は,ミトコンドリアを損傷し,インテグリンα4β1を通じて脂質代謝を妨害し,α-シヌクレインの集積を引き起こすことで,パーキンソン病の病理性を悪化させる. cFnをターゲットにすることで PDの新たな治療法が提供されるかもしれません

キーワード:
フィブロネクチンミトコンドリア機能障害パーキンソン病ポリ (ADP−リボース) (PAR) ポリメラーゼ-1ステアロイル-コア不飽和剤α-シヌクレイン

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Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons10:03

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