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関連する概念動画

Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
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Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

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Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
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Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

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Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Chronic Obstructive Pulmonary Disease-I: Introduction01:20

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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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ERS/EULARの臨床実務ガイドライン

Katerina M Antoniou1, Oliver Distler2, Ana-Maria Gheorghiu3

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まとめ

新しい臨床実践ガイドラインは,結合組織疾患 (CTD) の患者の間隔性肺疾患 (ILD) の管理のための勧告を提供します. これらのガイドラインは,CTD-ILDの治療を標準化し,患者の治療結果を改善することを目的としています.

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科学分野:

  • 肺病とリウマト病
  • クリニカル・プラクティスのガイドライン
  • 証拠 に 基づく 医学

背景:

  • インタースティシャル肺疾患 (ILD) は,結合組織疾患 (CTD) の深刻な合併症であり,著しい罹病率と死亡率をもたらします.
  • CTD-ILDのスクリーニング,診断,治療,フォローアップの標準化されたアプローチは,患者のケアを最適化するために不可欠です.

研究 の 目的:

  • 各種CTDの患者におけるILDの管理のためのエビデンスに基づく臨床実践ガイドラインを策定する.
  • CTD-ILDのスクリーニング,診断,治療,モニタリングに関する標準化された勧告を提供すること.

主な方法:

  • 欧州呼吸器学会と欧州リウマチ学協会連合の共同タスクフォースが招集されました.
  • 推奨事項は,PICOとナラティブ質問に基づいて,GRADEの方法論と決定のための証拠の枠組みを使用して策定されました.
  • 肺科医,関節科医,病理科医,放射線科医,方法学者,患者代表による専門家のコンセンサスがプロセスを導きました.

主要な成果:

  • このタスクフォースは,全身性硬化症,リウマチ性関節炎 (RA),イディオパシー性炎症性筋病症,シェーグレン病 (SjD),全身性白血球性狼 (SLE),および混合結合組織疾患 (MCTD) を含む複数のCTDに関する25のPICOと28のナレーション質問に関する勧告を作成した.
  • MCTD,SjD,SLEにおけるILD進行リスク評価の特定の側面,およびRA以外のCTD-ILDにおけるピルフェニドンの使用については,十分な証拠がないため,推奨はできなかった.
  • スクリーニング,診断,モニタリング,治療アルゴリズムは,臨床実践をサポートするために開発されました.

結論:

  • ガイドラインは,CTD-ILDを管理する臨床医のための実用的で根拠に基づいた勧告を提供します.
  • 管理戦略を洗練するためにさらなる研究が必要であることを強調した.
  • 勧告は,CTDに関連した腸内肺疾患の患者の治療を標準化し,治療結果を改善することを目的としています.