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Updated: Sep 8, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

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A型コレステロール依存型サイトリンがNLRP3炎症体の活性化のためにトランスゴルギネットワークに転位する

Nanyang Xiao1, Airi Kogishi1, Lisa Radochonski1,2

  • 1Department of Microbiology, University of Chicago, Chicago, IL, USA.

Nature immunology
|September 5, 2025
PubMed
まとめ

コレステロール依存型サイトリン (CDC) は,トランス・ゴルギネットワーク (TGN) を改造して,NLRP3炎症体を活性化させる. この細菌毒素のメカニズムは,毛穴形成とは異なり,免疫反応のための細胞内臓細胞の操作を含みます.

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Post-translational Translocation of Proteins to the RER

A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
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Hsp40 and Hsp70 chaperone molecules bind the translated proteins in the cytosol to prevent their folding. The chaperone binding helps to keep the signal...
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Export of Misfolded Proteins out of the ER

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Cotranslational Protein Translocation

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Protein Translocation Machinery on the ER Membrane

The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
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In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
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