低所得国から中所得国における高リスクおよび50歳以上の成人の呼吸器共膜ウイルス流行病学と臨床的負担:人工知能を活用した体系的な文献レビュー
Adriana Guzman-Holst1, Digant Gupta2, Amandeep Kaur2
1GSK Vaccines, Avenue Fleming 20, 1300, Wavre, Belgium. adriana.x.guzman@gsk.com.
Infectious diseases and therapy
|September 5, 2025
まとめ
開発途上国における高リスクの成人および高齢者における呼吸器同胞性ウイルス (RSV) に関するデータは限られている. 入手可能な証拠は,RSVがこれらの脆弱な集団に重大な影響を及ぼし,さらなる研究が必要であることを示唆しています.
科学分野:
- * 疫学と公衆衛生
- * 感染症
- * ウイルス学
背景:
- * 呼吸器シンシチアルウイルス (RSV) は,特に脆弱な成人の集団において,重大な健康上の負担を伴う.
- * 開発途上国における高リスク成人 (18~59歳) と50歳以上の成人のRSV疫学および臨床影響に関するデータは少ない.
- * これらの人口におけるRSVの負担を理解することは,標的型の介入と公衆衛生戦略にとって極めて重要です.
研究 の 目的:
- 高リスクおよび高齢者 (≥50歳) のRSVの流行病学および臨床負荷に関する利用可能なデータを,開発途上国に焦点を当てて,体系的にレビューし,統合する.
- * これらの集団におけるRSVの発生率,流行,疾患の重症度,および死亡率に関する証拠のギャップを特定する.
主な方法:
- * 2000年以降の論文の体系的な文献レビュー
- * MEDLINEとEMBASEで行われた検索,灰色の文献と会議要約で補完された.
- タイトル/概要のAI駆動のスクリーニングに続いて,全文のレビューと優先順位付け.
主要な成果:
- * 引用は77件あり,69件は疫学的および臨床的負担に関する関連データを提供した.
- * RSVの発生,流行,サブタイプ分布に関するデータは限られた.
- * RSV陽性率 (高リスクの成人では1. 5~31. 9%,呼吸器疾患の50歳以上の成人では0~9. 1%),季節性,合併症,および死亡率 (死亡率はそれぞれ15. 2%, 27. 0%) について十分な証拠が存在しました.
結論:
- * 開発途上国における高リスクおよび高齢者のRSV流行病学に関する重要な証拠のギャップが残っています.
- * データが限られているにもかかわらず,現在の発見は,RSVがこれらの集団に重大な健康上の悪影響を及ぼすことを示しています.
- * これらの脆弱な集団におけるRSVの負担を完全に理解し,対処するには,さらなる研究とデータ生成が不可欠です.
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