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Updated: May 5, 2026

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

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メラノーマにおけるLRP2発現は,トランジタリー細胞状態,T細胞浸透の増加と関連しており,IFNyシグナル伝達によって上位調節される

Martin Q Rasmussen1, Marie L Bønnelykke-Behrndtz2,3, Camilla Merrild1

  • 1Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Pigment cell & melanoma research
|September 6, 2025
PubMed
まとめ

低密度リポプロテイン受容体関連タンパク質2 (LRP2) は,メラノーマで獲得され,特定の細胞状態に関連しています. インターフェロン・ガンマ信号はLRP2発現を誘導し,よりよいメラノーマの予後と相関する.

キーワード:
LRP2 について区分するエピジェネティクス炎症インターフェロンメガリンメラノーマ

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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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