口腔疾患を含む多発性疾患と因果関係がある
A O Esemezie1,2, D J Lizotte2,3, G Tsakos4
1Dentistry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Journal of dental research
|September 6, 2025
まとめ
経済的・社会的資本の低さを含む社会的逆境は,高齢者の口腔疾患 (OC) と口腔疾患を含む多発性疾患 (MIOC) のリスクを因果的に増加させます. これらの効果は中年層で最も顕著でした.
科学分野:
- 健康の社会的決定因子
- 口腔衛生 疫学
- ゲロントロジーと老化に関する研究
背景:
- 根本的な原因理論は 社会的要因が病気に影響を及ぼすことを示唆しますが 口腔の健康に対する直接的な因果関係は不明です
- 経済的・社会的資本の低さを含む社会的逆境は,口腔や全身疾患を含む様々な病気と関連しています.
- 社会的逆境から口腔疾患や 多病性への因果関係を理解することは公衆衛生の介入において極めて重要です
研究 の 目的:
- 口腔疾患 (OC) の発達に対する社会的逆境の因果的影響を推定する.
- 口腔疾患 (MIOC) を含む多発性疾患に対する社会的逆境の因果的影響を評価する.
- 中年および高齢者の年齢や性別によってこれらの因果的な影響が異なるかどうかを調べる.
主な方法:
- カナダの長期老化研究 (CLSA) の2つの波 (2011年,2018) の分析.
- 低所得と社会資本 (地域社会参加,社会関係) によって定義される社会的逆境
- OCとMIOCの開発の因果確率比率 (OR) を推定するために使用される逆確率重み付けのロジスティック限界構造モデル.
主要な成果:
- 社会的逆境は7年間にわたって OC (OR=1.9) とMIOC (OR=1.7) の発症確率を大幅に増加させた.
- 社会的逆境の因果的な影響は中年のサブグループで最も強かった.
- 同様のOCとMIOCの増加率は,社会的逆境を経験している男性と女性の両方で観察されました.
結論:
- 社会資本と経済資本は,口腔疾患と老化集団の多病性の発達と因果的に結びついている.
- 健康的な高齢化を促進し,健康格差を減らすために,社会や生活条件をターゲットにした介入は不可欠です.
- 発見は,口腔衛生と全体的な全身的健康戦略における社会経済的要因への対処の重要性を強調しています.
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