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Updated: Sep 8, 2025

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
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Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

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鉛による神経機能障害におけるP62/Nrf2/Keap1信号経路の役割

Dongjie Peng1,2, Peiqi Wei1,2, Zhenning Li1,2

  • 1School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.

CNS neuroscience & therapeutics
|September 6, 2025
PubMed
まとめ

鉛の曝露はP62/Keap1/Nrf2経路を妨害し,酸化ストレスを増加させ,タウタンパク質を蓄積することによって神経変性を引き起こす. 抗酸化剤とオートファギーの治療は これらの効果を軽減するのに有望です

キーワード:
P62/Nrf2/Keap1 についてオートファジー鉛神経機能障害酸化ストレス

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