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Updated: Sep 8, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
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Antigenic Liposomes for Generation of Disease-specific Antibodies

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遅発ミアステニア・グラビスにおける明確な免疫学的な特徴: 探索性タンパク質学研究からの洞察

Bhaskar Roy1, Jiaxin Chen2,3, Fatemeh Khani-Habibabadi1,4

  • 1Department of Neurology, Yale School of Medicine, New Haven, CT, USA.

Annals of neurology
|September 6, 2025
PubMed
まとめ

遅発のミアステニア・グレイビス (LOMG) は,早期発症のミアステニア・グレイビス (EOMG) と比べて,明確な免疫の違いを示しています. Proteomicsは,LOMGの潜在的なバイオマーカーとして,IL18R1,CXCL17,CCL11を含む特定の炎症性タンパク質を特定しました.

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Immunolabelling Myofiber Degeneration in Muscle Biopsies06:37

Immunolabelling Myofiber Degeneration in Muscle Biopsies

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The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy

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Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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