免疫低下患者のデング熱: 系統的レビューとメタ解析
Juthaporn Cowan1, Viravarn Luvira2,3, Sivaporn Gatechompol4
1Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, Canada.
Journal of travel medicine
|September 6, 2025
まとめ
デング熱は,特に幹細胞移植 (HSCT) の後,免疫機能が低下した個体では重症でしばしば致命的です. このウイルスの感染は長期にわたって持続し,免疫機能が低下した旅行者にリスクをもたらします.
科学分野:
- 感染症
- 免疫学
- 公衆衛生
背景:
- 世界的にデング熱と免疫不全の発生率が上昇しています.
- 免疫不全の集団における重度のデング熱の流行に関するデータは限られている.
- 免疫不全の旅行者を導くための証拠が必要です.
研究 の 目的:
- デング熱の発生頻度と 免疫機能低下者のアウトカムを 体系的に検討し,メタ分析する.
- 既存の研究におけるバイアスのリスクを評価する.
- 臨床管理と旅行のアドバイスを伝えるため
主な方法:
- 関連する研究の体系的なレビューとメタ解析
- 非人間用品やレビュー用品を除外する.
- ROBINS-Eツールによるバイアスのリスク評価
主要な成果:
- バイアスのリスクが高かった.
- デング熱の発生頻度は0.3%から6.3%でした.
- 重度のデング熱と死亡率は,特にHSCT患者 (66. 7%) で顕著でした.
- デング熱のRNAは尿で最大2年検出され,生存可能なウイルスは9ヶ月で分離される.
結論:
- デング熱は,特にHSCTを受けた免疫機能が低下した個体において,重症度および死亡リスクが高い.
- ウイルスの長時間持続は重要な懸念事項です.
- この調査結果は 慎重に旅行のアドバイスや 管理戦略の必要性を強調しています
関連する概念動画
Immunodeficiency Diseases
1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.2K
Factors Affecting the Risk of Infection
12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
Pulmonary Tuberculosis I
321
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
321
Development of Immunocompetence
444
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
444


