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Updated: Sep 8, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1

Published on: April 16, 2021

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ssDNAとssRNAはSAMHD1の相凝縮を促進する

Brandon E Smith1, Ankita Pohnerkar1, Benjamin Orris1

  • 1Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, United States.

Biochemistry
|September 6, 2025
PubMed
まとめ

SAMHD1タンパク質は,GTPによって調節される核酸で液体状の滴状に凝縮されます. この液体-液体相分離 (LLPS) は,がんとウイルス感染症の治療に意味があります.

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