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Updated: Sep 8, 2025

Deciphering Molecular Mechanism of Histone Assembly by DNA Curtain Technique
06:32

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パラスペックルタンパク質NONOは,NSD1をアロステリックに刺激することによって活性クロマチンを調節する

Chen-I Hsu1, Shenglin Mei2, Justin Demmerle3

  • 1Virginia Tech Fralin Biomedical Research Institute Cancer Research Center DC, Children's National Research & Innovation Campus, Washington, DC, USA; Graduate Program in Biomedical and Veterinary Sciences (BMVS), Virginia Tech, Blacksburg, VA, USA.

Cell reports
|September 6, 2025
PubMed
まとめ

核受容体結合セットドメインタンパク質1 (NSD1) は,NONOタンパク質と相互作用するPWWP2ドメインを通じて活性化する必要があります. この相互作用は活性クロマチンの形成に不可欠であり,神経発達障害にも影響を及ぼします.

キーワード:
CP: 分子生物学CP: 神経科学MRXS34症候群ソトス症候群活性クロマチンエピジェネティクス神経分化神経発達障害核のパラスペックル幹細胞

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