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Updated: Sep 8, 2025

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
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転写強化関連領域 (TEAD) 阻害剤としてのスルフォナミド誘導体の発見と特徴付け:肝細胞癌を標的とする新しいアプローチ

Yang Lu1, Jian Gao2, Jun Mo2

  • 1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, PR China.; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.

Bioorganic chemistry
|September 6, 2025
PubMed
まとめ

研究者らは,肝細胞癌 (HCC) 治療のための転写強化関連領域 (TEAD) を標的とした新しい小分子阻害剤C11を特定した. この化合物は,HCC細胞の生存能力を効果的に低下させ,TEADに依存する遺伝子を抑制し,新しい治療戦略を提供します.

キーワード:
肝細胞がんトランスクリプション強化関連領域仮想スクリーニング

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