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Updated: Sep 8, 2025

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
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Published on: December 9, 2015

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合理的な阻害剤設計と併用療法により,RET変異がんにおける耐性を克服する

Ting Wang1, Wenjie Jiang1, Liyan Yang1

  • 1Department of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Bioorganic chemistry
|September 6, 2025
PubMed
まとめ

RETを標的とする治療法は 伝統的なマルチキナーゼ阻害剤を超えて 癌の薬剤耐性を克服するために進化しています 新しい阻害剤と組み合わせた戦略は,RET誘発がんにおける有効性と安全性の改善を約束しています.

キーワード:
併用療法薬剤耐性のメカニズム精密薬の開発RET阻害剤

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