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Updated: Sep 8, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
11:04

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

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新しいベンゼンビスルフォナミドの合成 炭酸アンヒドラゼとコレインエステラゼ阻害性

Uğur Canoğlu1, Akın Akıncıoğlu2, Necla Öztaşkın1

  • 1Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Türkiye.

Bioorganic chemistry
|September 6, 2025
PubMed
まとめ

新しいベンゼンビスルフォナミドが合成され,酵素阻害について評価された. 化合物20と21は,アルツハイマー病の可能性を示唆する重要なブチリルコリンエステラス (BChE) 活性を示した.

キーワード:
AChE について非対称なスルフォナミドBChE についてベンゼンビスルフォナミドベンゼンサルフォナミドhCA I についてhCA II について

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Chlorination and bromination are important classes of electrophilic aromatic substitutions, where benzene reacts with chlorine or bromine in the presence of a Lewis acid catalyst to give halogenated substitution products. A Lewis acid such as aluminium chloride or ferric chloride catalyzes the chlorination, and ferric bromide catalyzes the bromination reactions. During the bromination of alkenes, bromine polarizes and becomes electrophilic. However, in the bromination of benzene, the bromine...
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