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Updated: Sep 8, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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トリアゾール[1,5-a]ピリミジン誘導体の設計,合成および生物学的評価

Assem H Eldeeb1, Mai I Shahin1, Maiy Y Jaballah1

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, P.O. Box 11566, Abbassia, Cairo, Egypt.

Bioorganic chemistry
|September 6, 2025
PubMed
まとめ

新しいトリアゾロピリミジン化合物は,複数のキナーゼを阻害することによって強力な抗癌活性を示しています. 化合物12bと12cは,がん細胞に対する広範囲の抗増殖効果を示し,正常な細胞に対する毒性は最小限である.

キーワード:
CDK2 についてEGFRマルチキナーゼ阻害剤合成トルカトリアゾール[1,5-a]ピリミジンVEGFR2 について

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