多発性硬化症患者の不安症状に対する運動介入の効果:体系的なレビューとメタ解析
Yvonne C Learmonth1, Megan R Hawkins2, Amalia Karahalios3
1Discipline of Exercise Science, Murdoch University, Perth, WA, Australia; Perron Institute for Neurological and Translational Science, Perth, WA, Australia; Personalised Medicine Centre, and Centre for Health Ageing, Healthy Futures Institute, Murdoch University, Perth, WA, Australia.
Multiple sclerosis and related disorders
|September 6, 2025
まとめ
運動は多発性硬化症 (MS) の患者における不安症状の軽減にわずかな効果を示している. このアクセシブルな介入は 多発性硬化症患者の不安管理に 有望なアプローチです
科学分野:
- 神経科学とリハビリテーション
- 精神科 と 精神 保健
- 運動科学
背景:
- 多発性硬化症 (MS) と診断された人では,不安症状が多く見られます.
- この集団における不安の管理に 効果的で簡単に利用可能な介入が 求められています
研究 の 目的:
- MS患者の不安症状に対する運動介入の影響を体系的に評価する.
- 不安を軽減するための運動の効果に影響を与える特徴を特定する.
- 関連する研究における介入デザインの報告の質を評価する
主な方法:
- MSの患者を対象としたランダム化制御運動試験の 体系的なレビューとメタ解析を実施しました
- 2024年11月までの複数のデータベース (MEDLINE,Embase,PsycINFO,CENTRAL,CINAHL,Scopus,Web of Science,PEDro) で検索しました.
- ランダム効果モデルを用いて介入後の不安症状の差異を分析し,バイアスのリスクをコクランリスク・オブ・バイアス 2.0で評価した.
主要な成果:
- 多発性硬化症患者の不安症状の軽減に対する運動の小さな,統計的に有意な効果を特定した (SMD: 0. 26).
- ランダム化比較試験を含む18件で,適度な異質性が見られた.
- すべての試験でバイアスのリスクが高いのは,自己報告の測定値と非ブラインド参加者に依存しているためであり,介入の設計要素に関する報告は限られている.
結論:
- 運動は多発性硬化症患者の不安症状を緩和する有益な効果を示しています
- 運動はMSの不安管理の 安全で手頃な方法であり 一般的に健康に有益です
- 将来の研究は,堅牢な試験設計,事前登録,介入の構成要素の詳細な報告を優先すべきです.
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