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第1条 メトフォーミンは,miR-130a-5pが調節するPI3K/AKTシグナル伝達経路によって,H1N1誘発の肺上皮細胞のアポトーシスに影響する

Li Zhang1, Yan Li2, Kun Ye2

  • 1Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, Yunnan Province, China; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650500, Yunnan, China; Department of Geriatrics, The First People's Hospital of Yunnan Province, Kunming, 650021, Yunnan, China; Yunnan Province Clinical Research Center for Geriatrics, Kunming, 650021, Yunnan, China.

Biochemical and biophysical research communications
|September 6, 2025
PubMed
まとめ

メトフォーミンは,PI3K/ AKT経路を阻害するmiR- 130a- 5pを上調することで,H1N1インフルエンザによる肺損傷を緩和します. これは繊維症,炎症,アポトーシスを軽減し,H1N1誘発肺疾患の潜在的な治療戦略を提供します.

キーワード:
アポトーシスH1N1 インフルエンザメトホルミンPI3K/AKT信号経路について肺繊維症miR-130a-5pについて

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