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Updated: Sep 8, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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NDUFS8は,ミトコンドリア機能を強化し,HUWE1依存の分解を回避することによって,肝細胞がんの成長を促進する

Xuxia Zhu1, Ping Lu1, Liang Ji1

  • 1Department of General Surgery, Affiliated Zhangjiagang Hospital of Soochow University.

Translational oncology
|September 6, 2025
PubMed
まとめ

NADH:ウビキノン酸化還元酵素のコアサブユニットS8 (NDUFS8) は,肝がんで過剰発現し,ミトコンドリアの活性を増大させることで腫瘍の成長を促します. NDUFS8またはそのレギュレータであるHUWE1をターゲットにすることで,肝細胞癌の新たな治療法を提供することができる.

キーワード:
アポトーシスHCC についてミトコンドリアNDUFS8,HUWE1 について

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