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Updated: Sep 8, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Published on: November 10, 2017

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適度なCYP3A阻害剤との薬物相互作用の評価のためのヒトの血内の内生性バイオマーカーとしての1β-Hydroxydeoxycholic acid

Yizhe Chen1, Runlan Huo1, Brian Melo1

  • 1Translational Medicine and Clinical Pharmacology, Bristol-Myers Squibb, Princeton, New Jersey.

Drug metabolism and disposition: the biological fate of chemicals
|September 6, 2025
PubMed
まとめ

血中の総1β- 酸化塩酸 (1β- OH DCA) は,薬物相互作用 (DDI) のバイオマーカーとしての可能性を示している. このバイオマーカーは,他の方法とは異なり,中程度のCYP3A阻害と強いCYP3A阻害の両方を予測することができます.

キーワード:
1β-ヒドロキシデオキシコール酸固有のバイオマーカー人間の血適度なCYP3A阻害剤

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