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Updated: Sep 8, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
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Published on: May 2, 2025

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生まれながらの免疫チェックポイントブロック癌療法としての超長期の薬物標的在留時間を備えたENPP1阻害剤

Songnan Wang1, Randolph M Johnson2, Jacqueline A Carozza3

  • 1Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA.

Cell reports. Medicine
|September 6, 2025
PubMed
まとめ

新しい薬であるSTF-1623は,腫瘍におけるENPP1 (エクトヌクレオチド・パイロフォスファターゼ/フォフォディエステラーゼ1) を効果的に抑制し,抗腫瘍免疫力を高める. この標的型アプローチは,がんの免疫療法反応率を改善する見込みを示しています.

キーワード:
STINGアゴニスト乳がん大腸がんグリオブラストーマ免疫伝達物質臓がん

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