S100A12は,慢性前立腺炎/慢性骨盤痛症候群の患者における炎症および痛みの症状と相関する
Marc Manthey1, Temuujin Dansranjav1, Hang Yan1
1Clin(i)c of Urology, Pediatric Urology and Andrology, Justus-Liebig-University Giessen, Rudolf-Buchheim-Str. 7, 35392 Giessen, Germany; Molecular Andrology, Justus-Liebig-University Giessen, Schubertstr. 81, 35392 Giessen, Germany.
The journal of pain
|September 6, 2025
まとめ
慢性的な前立腺炎/慢性的な骨盤痛症候群 (CP/CPPS) は,大きな骨盤痛を伴う. この研究は,S100A12をCP/CPPSの若い男性における炎症と痛みを関連付ける重要なバイオマーカーとして特定しています.
科学分野:
- 泌尿器科
- 免疫学
- 神経科学
背景:
- 慢性前立腺炎/慢性骨盤痛症候群 (CP/CPPS) は50歳未満の男性に多く見られ,衰弱する骨盤痛と生活の質の低下を引き起こします.
- CP/CPPSの現在の診断とメカニズムの理解は,信頼できるバイオマーカーの欠如によって制限されています.
- 新しいバイオマーカーの調査は,患者の評価を改善し,ターゲットを絞った治療法の開発に不可欠です.
研究 の 目的:
- CP/CPPSにおける炎症と神経性疼痛を関連付ける潜在的なバイオマーカーとしてS100A12を調査する.
- 既存のマーカーと比較してS100A12の診断性能を評価する.
- CP/CPPS患者におけるS100A12と痛みの重度,炎症マーカー,生殖機能障害との関連を調査する.
主な方法:
- 90人のCP/CPPS患者と90人の健康な対照群を対象とした症例対照試験.
- 精液,血清,前立腺マッサージ後の尿のS100A12値の分析
- 炎症マーカー,痛みスコア (CPSI,IPSS),精子パラメータによる相関分析
- 診断性能のための受信機動作特性 (ROC) 分析
- 前立腺の単細胞RNA配列解析データと白血球遺伝子発現の分析 (RAGE,CALCA) のシリコ分析
主要な成果:
- CP/ CPPS患者の精液と血清では,対照群と比較してS100A12濃度が有意に上昇した.
- 精子S100A12は炎症マーカー,痛みのスコア,精子の欠陥と強い相関関係を示し,精子の運動性と活力と逆相関関係を示した.
- S100A12は白血球数,IL-8,および粒細胞弾性酶と比較して優れた診断性能 (AUC=0. 90) を示した.
- シリコと遺伝子発現の分析では,RAGEとCALCAによるIL-8媒介の炎症と白血球と神経の相互作用におけるS100A12の役割が示唆された.
結論:
- S100A12は,若いCP/CPPS患者の炎症と痛みの有望なバイオマーカーです.
- 発見は,S100A12,RAGE,およびCP/CPPSの病原性における関連するシグナル伝達経路を含む神経免疫相互作用を示唆しています.
- S100A12は,疼痛,炎症,生殖機能不全に対処するCP/CPPSの診断ツールと治療標的としての可能性を秘めています.
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