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Updated: Sep 8, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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長い非コーディングRNASNHG12は,E3リガゼTRIM25を標的にすることでKEAP1の安定性とフェロプトーシス感受性を定義する

Yubo Guo1, Shuang Zhu2, Wenjie Wu3

  • 1State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Hongshan Laboratory, Wuhan, Hubei, 430070, China.

The Journal of biological chemistry
|September 6, 2025
PubMed
まとめ

この研究では,SNHG12が癌治療に不可欠な細胞死の一種であるフェロプトーシスの新しい調節剤であると特定しました. SNHG12のアップレギュレーションは,TRIM25との相互作用によってフェロプトーシスを促進し,新しい治療目標を提供します.

キーワード:
KEAP1 についてNRF2 についてSNHG12トリム25フェロプトーシス

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